Galactosyltransferase Inhibitors

Authors

  • I. Jambal Department of Chemistry of Natural Compounds, Institute of Chemical Technology, Prague
  • K. Kefurt Department of Chemistry of Natural Compounds, Institute of Chemical Technology, Prague
  • J. Moravcová Department of Chemistry of Natural Compounds, Institute of Chemical Technology, Prague

Keywords:

galactosyltransferase, mechanism, inhibitors

Abstract

Oligosaccharides in glycoconjugates form a sugar code in cell-cell recognition processes. Since galactosyltransferases are responsible for the biosynthesis of galactose-containing oligosaccharides, inhibitors of these enzymes are targets for drug design. In this review, the current state of the development of galactosyltransferase inhibitors, based on the donor and transition-state structures and bisubstrate analogues, is summarised.

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Published

2012-04-15

How to Cite

Jambal, I., Kefurt, K., & Moravcová, J. (2012). Galactosyltransferase Inhibitors. Chemické Listy, 106(4), 283–288. Retrieved from http://www-.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/978

Issue

Vol. 106 No. 4 (2012)

Section

Articles